To further search for the mechanism involved in the regulation of CRC by high expression of CEP55, we validated the protein expression of p53 and p21 in SW480 and Caco‐2 cells based on our screen p53/p21 signaling pathway, and the results indicated that high CEP55 expression could negatively activate the p53/p21 signaling pathway, thus having an impact on CRC malignant progression (Figure 7C). Here, CEP55 is linked to colorectal carcinoma.