Although the specific role of FGF‐23 in the development of cardiovascular disease remains unresolved, this early elevation pre‐hyperphosphatemic stimulus may be an index of susceptibility for vessels to calcify or identify vessels that are in the early phases of VC with transdifferentiating vascular smooth muscle cells (VSMCs) that are producing FGF‐23. Here, FGF23 is linked to cardiovascular disorder.