Postmortem studies of AD patients have also demonstrated that cortical tau pathology is associated with the WM Wallerian degeneration protease (i.e., calpain) (McAleese et al., 2017) and alterations in WM microstructural integrity detected by diffusion magnetic resonance imaging (dMRI) (Kantarci et al., 2017). Here, MAPT is linked to Alzheimer disease.