MAPT and Schnyder corneal dystrophy: Supplementary Fig. S2 lists the tau+ prevalence in each group. While all groups had a similar pattern of tau gradients across ROIs, the MCI group had a higher tau+ prevalence than the CN and SCD groups in almost every ROI. The ROIs with tau+ prevalence greater than 80% among all subjects were used as seeds for initiating the pathway searching process. The rationale for the threshold selection is discussed below (in Identified pathways session).