Recent neuroimaging studies reported detectable associations between tau and WM diffusion alterations in cognitively healthy older individuals, in atypical AD, as well as in individuals with pathologically-staged AD (Kantarci et al., 2017; Jacobs et al., 2018; Strain et al., 2018; Sintini et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.