These data suggested that the increased expression of these genes may be contributed by the presence of higher H3K4me3 signals in PTSD patients because the presence of H3K4me3 is associated with upregulation of the nearby genes due to chromatin accessibility made easier by the methylation of histone proteins (Wysocka et al. 2006). The gene discussed is H2BC12L; the disease is post-traumatic stress disorder.