However, future studies should investigate other potential neurobiological factors, such as distribution of tau pathology and involvement of other pathological mechanisms such as decreased Von Economo Neuron [50] density in the anterior cingulate cortex (associated with social behavior), as well as premorbid personality traits and social cognition in a prospective cohort of bvAD patients, in order to understand the peculiar behavioral presentation in this AD variant that seems to hold relatively little reference to our existing conception of clinico-anatomical relationships. The gene discussed is MAPT; the disease is Alzheimer disease.