APOE and early-onset autosomal dominant Alzheimer disease: The database from the Alzheimer Disease Neuroimaging Initiative, a larger study, showed that cortical thinning in temporal cortex was associated with more severe apathy over time after correcting for multiple covariates, such as sex, age, APOE genotype, premorbid intelligence, memory performance, processing speed, antidepressant use, and AD duration [22].