Nutlin‐3 preferentially sensitizes wild‐type p53‐expressing cancer cells such as the A549 lung cancer cell line [34], but our study shows that it also appears to work in mutant p53‐expressing cancer cells (TP53 T284P in the NCI‐H820 cell line; TP53 R273H in the NCI‐H1975 cell line; and TP53 P72R in the LG1049 PDX model). This evidence concerns the gene TP53 and lung carcinoma.