Furthermore, we found the upregulation of pro-apoptotic proteins Caspase3, Caspase8 and IGFBP-6, and downregulation of anti-apoptotic protein XIAP in ESCC cells with MEX3A knockdown, by which may MEX3A suppresses cell apoptosis of ESCC cells. Here, IGFBP6 is linked to esophageal squamous cell carcinoma.