IL‐17 (provided by γδ17 and CD4+ Th17 cells) is required for the initiation and progression of early pancreatic cancer: pancreatic cells sense IL‐17 in the TME through IL‐17 receptors and downstream signaling leads to the acceleration of pancreatic intraepithelial neoplasia [26]. This evidence concerns the gene IL17A and familial pancreatic carcinoma.