Digital karyotyping and multiplex PCR analysis of cell lines derived from established metastatic melanomas revealed DMD deletions in the M1 (in-frame deletion of exons 3–29), RPMI-7951 (in-frame deletion of exons 17–30) and WM-793 (out-of-frame deletion of exons 42–43) cell lines [21]. This evidence concerns the gene DMD and melanoma.