ADSL and Alzheimer disease: Moreover, the concept of this study was based on the hypothesis of amyloid cascade and neuroinflammation as the main pathomechanism involved in Alzheimer’s disease and especially on the idea that amyloid-β, as a member of AMPs (antimicrobial proteins), could have a beneficial effect on neuronal cells in the presence of bacterial LPS and that disturbance in the physiological pathways involving Aβ and causing neuroinflammation might be the underlying cause of Alzheimer’s disease development [64–66].