A study in individuals with Alzheimer’s disease found that the additional presence of LATE-NC was associated with an increased risk of agitation/aggression (Sennik et al., 2017), while a further report found no association between TDP-43 pathology in the dentate gyrus and prefrontal cortex and psychosis in Alzheimer’s disease (Vatsavayi et al., 2014). This evidence concerns the gene TARDBP and Alzheimer disease.