There is also evidence that LATE and Alzheimer’s disease may have distinct associated neurocognitive profiles; for example, higher verbal fluency and lower word list delayed recall test scores were seen in patients with hippocampal sclerosis pathology, 90% of whom were TDP-43 positive, versus those with Alzheimer’s disease pathology (Nelson et al., 2011). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.