In line with these results, a reduced cell invasion was observed when ZEB1 or ETAR was depleted, and miR-200b/c were overexpressed, or upon macitentan treatment (Fig. 6f and Supplementary Fig. 5e), indicating an ETAR-miR-200b/c-ZEB1 network involvement in the ET-1-driven tumor aggressiveness. The gene discussed is EDN1; the disease is neoplasm.