The fourth network was comprised of six out of 25 RV-responsive genes at the Epidermal Differentiation Complex (EDC) on chromosome 1q21.3 (SPRR1A, SPRR2A, SPRR2F, IVL, LCE1C, TCHH), the second most statistically significant childhood onset asthma locus22 (Fig. 6). This evidence concerns the gene SPRR2F and childhood onset asthma.