SPRR2A and childhood onset asthma: The fourth network was comprised of six out of 25 RV-responsive genes at the Epidermal Differentiation Complex (EDC) on chromosome 1q21.3 (SPRR1A, SPRR2A, SPRR2F, IVL, LCE1C, TCHH), the second most statistically significant childhood onset asthma locus22 (Fig. 6).