To address this gap in the literature, we went beyond morphological analyses by employing multi-parametric qMRI to study the effects of APOE-ε4, Family History (FH) of dementia and obesity on cortical and subcortical grey matter in 165 asymptomatic individuals from the Cardiff Ageing and Risk of Dementia Study (CARDS)42–44 (Table 1). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.