In line with the literature22, Arpc2−/− mice presented normal tail bleeding times and formed stable thrombi in a model of acute arterial thrombosis similar to Arpc2+/+ controls with platelet counts adjusted to the level of Arpc2−/− mice (Supplementary Fig. 4a–g, Supplementary Movie 5, and Supplementary Methods). Here, ARPC2 is linked to Arterial thrombosis.