Similar observations were retrieved from human hepatocellular carcinoma patients (n = 92), with inverse relation between IRF3 and TCF1/LEF1 (Fig. 7g and Supplementary Fig. S7c), and shorter survival time of patients with low IRF3 and high TCF1 and LEF1 expression (Fig. 7h). The gene discussed is IRF3; the disease is hepatocellular carcinoma.