IRF3 and neoplasm: Consistently, ICG-001 treatment downregulated the proliferation of IRF3-knockout cells to a level similar with wild-type cells (Fig. 4d), and tumor formation assays phenocopied this observation (Fig. 4e, f), with marked decrease of Ki67-positive cells (Fig. 4g) and reduced Wnt signaling activation (Supplementary Fig. S4l).