IRF3 and neoplasm: However, the decreased rate of tumor number in Apcmin/+ mice (67.4%) was higher than those in Apcmin/+ IRF3−/− mice (55%; Fig. 6h): Abx treatment reduced the average number of tumors per mice from 8.1 to 2.6 in Apcmin/+ mice, while reduced the number of tumors per mice from 22.9 to 10.3 in the Apcmin/+IRF3−/− mice.