IRF3 and infectious otitis media: However, we detected a higher level of ki67+ cells per crypt in the distal colon, para-cancerous and tumor tissues from IRF3−/− mice and IRF3fl/flVillincre upon AOM treatment (Fig. 2a–d), or from the bone marrow chimaera mice IRF3+/+ → IRF3−/− (Fig. 2e–f).