In addition to type 3 cytokine dysregulation, we reveal an association between mouse NEC and an increase in pro-inflammatory NKp46−RORγt+Tbet+ ILC3, alongside a reduction in presumably protective NKp46+RORγt+ ILC330, corroborating a protective role for this ILC3 subtype, as increased IL-17A+IL-22+ ILC3 populations were reported in P.UF1-gavaged mice that were protected against NEC43. Here, IL22 is linked to necrotizing enterocolitis.