CLCN2 and Leukoencephalopathy: Since GLIALCAM mutations entail a vacuolating human leukoencephalopathy (24), we previously generated Glialcam−/− mice (9) to study its interaction with ClC-2 and with MLC1, another binding partner of GlialCAM (24) that also underlies human leukoencephalopathy (80).