In contrast, regulation of membrane remodeling by the BIN1-dynamin 2 complex may be compromised in CNM patients by causing unstable T-tubules in BIN1-associated CNM (Fig. 5H, CNM ∗BIN1) or overfission of T-tubules in DNM2-associated CNM patients (Fig. 5H, CNM ∗DNM2). This evidence concerns the gene BIN1 and centronuclear myopathy.