Unexpectedly, a number of important immunological pathways were significantly enriched, specifically among cells from patients with influenza across a number of subsets: Compared to the influenza condition, both IFN-γ and IFN-α response pathways were significantly down-regulated within the COVID-19 condition for B cells, plasmablasts, CD8+ T cells, MCLPs, Tregs, PDCs, and monocyte/macrophage subsets (Fig. 5E and fig. This evidence concerns the gene CD8A and influenza.