PIK3CA and breast carcinoma: As can be observed in the IntoGene software, the main driver genes in breast cancer are TP53 and PIK3CA. Also, by reevaluating the CliVar database we observed that mutations of ERBB4 (c.421 + 58 A > G), PIK3CA (c.352 + 40 A > G) and KDR (c.3849–24C > A) have unknown significance (Fig. 3).