However, patients with higher levels of tumor-associated caspase-4 but positive for PD-L1 (Fig. 3a, black line) showed lower survival rate (p = 0.033) than patients with low caspase-4 but positive for PD-L1 (Fig. 3a, green line, n = 1/75, 1.3%, median survival = undefined). This evidence concerns the gene CASP4 and neoplasm.