Therefore, because we previously demonstrated that the majority of NSCLC patients were caspase-4 and K-Ras+, we used lung tissues of K-Ras LA1 and K-Ras LA1p53R172HB mice who were previously described by Prof. Quaglino’s laboratory [24] as a lung adenocarcinoma model that shows lung tumor lesions starting from 10 weeks of age. The gene discussed is CASP4; the disease is non-small cell lung carcinoma.