MYC and neoplasm: Interestingly, patients with high levels of tumor-associated caspase-4 but who were c-MyC negative (c-MyC−) still had lower survival rate (median survival = 2.036 years) (Fig. 3g, blue line), although it was higher than patients positive for both Caspase-4 and c-MyC (Fig. 3g, black line).