In adenocarcinoma patients, CASP4 positively correlated to 9 genes involved in gene expression (i.e. C-MYCT1, SRA1, GTF2B, EEF1A1, SP110, CNOT8), 186 genes involved in inflammation (i.e. CASP1–5, CARD16, CD63, HLA, IRF1, TLRs), 106 genes involved in cell proliferation (i.e. C-MYCT1, SRA1, RHOA, CDK7, RAB32, CD74, RRAS) and 17 genes involved in cell death (i.e. CASP5, ANXA5, BAK1, RIPK2, MLKL) (Fig. 2a). The gene discussed is RHOA; the disease is adenocarcinoma.