Similarly, in squamous carcinoma CASP4 positively correlated to 47 genes involved in gene expression (i.e. CREM, BATF, BZW1, HDAC9, STAT1–4), 303 genes involved in inflammation (i.e. AIM2, CASP5, CARD6–16–17-19, CCLs, ICOS, TLRs), 266 genes involved in cell proliferation (i.e. FAM107B, FGF7, IRF1–8-9, RASGRP3) and 63 genes involved in cell death (i.e. CASP8, ANXA3–5, FAS, GZMs, RIPK3) (Fig. 2b). This evidence concerns the gene ICOS and squamous cell carcinoma.