Nevertheless, it has to be noted that there was a group of patients who were PD-L1 negative and presented lower tumor-associated caspase-4 (Fig. 3a, red line; Fig. 3b, n = 15/75, 20%, % survival at 1 year = 85%) whose median survival rate was of 2.98 years. Here, CASP4 is linked to neoplasm.