TP53 and neoplasm: Noteworthy, the precursor form of caspase-11 was higher expressed in these latter mice compared to NMU-injected C57Bl/6, control (Ctr) mice (Fig. 4d), implying that not only K-Ras mutation, but also p53 genetic alteration could be implied in caspase-11-related pro-tumor activity in mice.