HMGB3 knockdown markedly increased the susceptibility of the cervical cancer cells to cisplatin (DDP), paclitaxel (TAX) and vincristine (VIN) treatment (Additional file 1: Figure S4A), resulting in a significant reduction in IC50 value (Additional file 1: Figure S4B) and a reduced colony formation (Additional file 1: Figure S4C). The gene discussed is HMGB3; the disease is cervical carcinoma.