Among these pathways, the PI3K-Akt signaling pathway, HIF-1 signaling pathway, fluid shear stress and atherosclerosis, calcium signaling pathway, cAMP signaling pathway, serotonergic synapse, thyroid hormone signaling pathway, regulation of lipolysis in adipocytes, and drug metabolism-cytochrome P450 were found to be related to the development of multiple cardiovascular diseases and were involved in CAD development and pathogenesis. The gene discussed is TG; the disease is atherosclerosis.