Among these pathways, the PI3K-Akt signaling pathway, HIF-1 signaling pathway, fluid shear stress and atherosclerosis, calcium signaling pathway, cAMP signaling pathway, serotonergic synapse, thyroid hormone signaling pathway, regulation of lipolysis in adipocytes, and drug metabolism-cytochrome P450 were found to be related to the development of multiple cardiovascular diseases and were involved in CAD development and pathogenesis. This evidence concerns the gene AKT1 and cardiovascular disorder.