IL6 and colorectal carcinoma: Table 3 shows that for subjects with a 1-SD increase in the circulating sRAGE level, the OR for CRC was increased (OR = 2.289; 95% CI = 1.037–5.051; P = 0.04) after adjustment for age; sex, BMI, smoking status, HOMA-IR score, and the levels of triglycerides, total cholesterol, LDL-c, HDL-c, and IL-6.