Compared with control participants, type 2 diabetes patients with CRC had significantly higher triglyceride, total cholesterol, IL-6, and circulating sRAGE levels, and a lower proportion of these patients used medicines, including insulin, metformin, thiazolidinedione, a-glucosidase inhibitors, NSAIDs and statins (all P < 0.05). This evidence concerns the gene INS and colorectal carcinoma.