SP1 and neoplasm: The abnormal activation of Sp1 could up-regulate the expression of tumor related factors and angiogenic factors, thus providing a good microenvironment for tumor growth, and promoting the proliferation, metastasis and angiogenesis of colon, gastric and pancreatic tumors and regulate apoptosis (Beishline and Azizkhan-Clifford 2015; Liu et al. 2018; Torabi et al. 2018).