VEGFA and neoplasm: Sp1 could interact with the promoter of vascular endothelial growth factor A (VEGFA), and up-regulate its expression, which promotes the proliferation of vascular endothelium, angiogenesis and vascular permeability, thus promoting the growth and metastasis of tumor via binding with VEGF receptor 2 (VEGFR2) (Chen et al. 2018; Vizcaino et al. 2015).