The expression of Sp1, VEGFA and MMP-2 in BC cells were detected by western blot and they all decreased after ZLM-7 treatment compared to control group. Compared with the ZLM-7 + inhibitor NC group, the expression of these proteins in the ZLM-7 + miR-212-3p group was significantly increased, but there was no significant difference between ZLM-7 + inhibitor NC group and ZLM-7 group (Fig. 2e, f). This evidence concerns the gene MMP2 and breast cancer.