AVPR2 and Leber hereditary optic neuropathy: Adeno-associated virus (AAV) expressing NDI1 (AAV-NDI1) was shown to protect retinal ganglion cells (RGCs) in a rotenone-induced murine model of LHON, significantly reducing RGC death by 1.5-fold and optic nerve atrophy by 1.4-fold and considerably preserving retinal function [328].