IL1B and Hepatic fibrosis: In this regard, Kuppfer cell activation leads to the production of many inflammatory cytokines, such as transforming growth factor beta 1 (TGF-b1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kb), and interleukin 1 beta (IL-1 β), related to the liver fibrosis process [115,116].