HLA-C and cardiac hypertrophy: Shirpoor and coauthors [59], through experiments on rats, showed the molecular mechanisms underlying heart hypertrophy: chronic nandrolone treatment with or without strenuous exercise causes a shift in the alpha and beta–myosin heavy chain (α-MHC/β-MHC) isoform expression manifested by elevation of β-MHC mRNA and the ratio of β-MHC mRNA/α-MHC mRNA expression, as well as an increase in the heart tissue of mono-amine oxidase (MAO) and calcium/calmodulin-dependent protein kinase II-δ activities (CaMKII-δ).