Similarly, in another study including a cohort of subjective memory complainers, a condition at risk for AD, the plasma Aβ1–40/Aβ1–42 ratio, turned out to be the best predictor of cerebral amyloidosis among a series of tested candidate biomarkers (e.g., β-site amyloid precursor protein cleaving enzyme 1 or BACE1, t-tau, NFL [72] (Table 3). This evidence concerns the gene NEFL and Alzheimer disease.