The second study including three separate cohorts with 589 individuals (controls, MCI, AD, and non-AD NDDs) revealed that plasma p-tau levels likewise assessed by means of the MSD platform increase with disease progression (from preclinical to frank dementia phases encompassing prodromal/MCI stage) and can distinguish AD dementia from non-AD dementia with excellent accuracy (Table 3). The gene discussed is MAPT; the disease is dementia.