We described how three important deafness genes (DFNA5, DFNA59 and connexin26) linked with autophagy are sensitive to oxidative stress, inducing SNHL, or age-related hearing loss (ARHL), and that autophagy deficiency caused by autophagy- and lysosomal-function-related genes can induce hearing impairment. The gene discussed is GSDME; the disease is hearing loss disorder.