This research group also indicated that two NRF2 target genes (PRKCE and TGFβ1) (p-value < 4 × 10−2) were detected in a large cohort of 4091 individuals with hearing phenotype (including 1076 presbycusis patients and 1290 healthy matched controls from Europe, Caucasus, and Central Asia) by a genome-wide association study. This evidence concerns the gene NFE2L2 and presbycusis.