In this conceptual framework, our objective is to assess the role of SNPs of these three genes, CTLA-4 (rs3087243, rs231775 and rs5742909), CD80 (rs57271503) and CD86 (rs1129055), as possible response predictors (EULAR response, LDA and remission) in patients with RA treated with ABA. Here, CD80 is linked to rheumatoid arthritis.