However, in this review, we are going to emphasize three signaling pathways (Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT), Wnt/β-catenin, and PI3K/AKT pathways) that have been reported to be closely linked to CRC development due to the disruptions by elevated oxidative stress [65,66,67]. Here, AKT1 is linked to colorectal carcinoma.