MTHFD2 and colorectal carcinoma: This study found that elevated levels of methylenetetrahydrofolate dehydrogenase (MTHFD2), an NADPH generating enzyme, facilitated CRC cell growth and metastasis when MTHFD2 was transcriptionally upregulated by c-Myc through KRAS downstream effectors, including PI3K/AKT and ERK pathways [84].