The 100% of all the proteins included in intracellular trafficking group are over increased in HD groups with the 90% and 10% belonging to UNIQUE HD and to >HD respectively (Figure 1 and Figure 3C); in detail as listed in Table 1 we identified 25 proteins belonging to the Rab family, a member of the Ras superfamily of small G proteins. This evidence concerns the gene RAC2 and Huntington disease.