ICOS and synovial sarcoma: According to experimental studies, a recent report for ALPN-101, a fusion protein simultaneously inhibiting CD28 and ICOS costimulatory pathways, showed better suppression in comparison to abatacept, by reducing release of pro-inflammatory cytokine such as TNF-α, IFN-γ and IL-6 in peripheral blood mononuclear cells from SS patients [130].