Enrichment analysis of ACC tumors with upregulated vs unaltered ABAT transcripts showed that HSD3B2, the gene encoding the steroidogenesis enzyme 3β-HSD (3-beta-hydroxysteroid dehydrogenase), was underexpressed in tumors with upregulated ABAT transcripts (Figure 4b, left panel), consistent with these tumors largely having originated from patients without excess cortisol. Here, HSD3B2 is linked to adrenal cortex carcinoma.