Figure 7a visualizes the number of patient tumors expressing combinations of these various transcripts. Based on transcript analysis, the most abundant putative heteropentameric receptor configurations were permutations of α3/5β2/3γ1/δ/ε (Figure 7b). GABRA5, the most abundantly expressed α subunit-encoding gene, was upregulated in 10% of ACC tumors. GABRA5 upregulation co-occurred with that of GABRB3 (log2 odds ratio > 3; q = 0.003), the gene adjacent to GABRA5 on chromosome 15 [26]. This evidence concerns the gene GABRA5 and adrenal cortex carcinoma.