Additionally, the mutual exclusivity of ABAT upregulation with that of AKR7A2 (which encodes succinic semialdehyde reductase (SSR) and may lead to the diversion of GABA carbons out of the GABA shunt), and the under-expression of AKR7A2 in ACC tumors with upregulated ABAT transcripts may further ensure that the GABA shunt in these tumors culminates with the production of succinate. This evidence concerns the gene AKR7A2 and adrenal cortex carcinoma.