Genome-wide association and gene expression profiling have identified genes with a number of polymorphisms associated with NAFLD development such as Patatin-like phospholipase domain containing 3 (PNPLA3), Transmembrane protein 6 superfamily member 2 (TM6SF2), GCKR, CETO, MBOAT7, MTTP, SOD2, GST, APOC3, IL-6, TNF-a, PPAR-a, just to mention a few [52]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.