Worms expressing mutant human tau associated with cases of FTD and Parkinsonism linked to chromosome 17 (P301L, V337M, R406W, F3ΔK280, and A152T), as well as hyperphosphorylated tau, had more severe phenotypes and a greater accumulation of insoluble tau than C. elegans expressing tau WT [25,26,27,28,55]. Here, MAPT is linked to frontotemporal dementia.