AKT1 and cancer: Previous studies showed that CCM-induced cancer cell apoptosis involved multiple targets and signaling pathways, including increasing the permeability of mitochondrial membrane (PT pore opening), downregulation of antiapoptotic proteins Bcl-2, Bcl-XL, and XIAP, upregulation of proapoptotic proteins Bax and Bak, caspase-3 activation, the release of cytochrome c, as well as the inhibition of PI3K/AKT and NF-κB survival pathways [66,67].