A secreted ECM glycoprotein collagen triple helix repeat containing 1 (CTHRC1) correlated with high density of M2-like tumour-associated macrophages (CD68+/CD163+) in patients with endometrial cancer [105], whilst CTHRC1 stimulated the recruitment of macrophages in vitro through integrinβ3/PI3K/Akt/CX3CR1 signalling [105]. This evidence concerns the gene CTHRC1 and endometrial cancer.