In pancreatic cancer, collagen topography rather than chemokine concentration determined migration of tumour-activated T-cells, such that even in the presence of high levels of the T-cell chemoattractants CXCL10 or CCL4, motility was prevented by the presence of the high-density collagen fibers surrounding tumour cell nests [56]. This evidence concerns the gene CXCL10 and neoplasm.