MMP2 and glioblastoma: In glioblastoma cells, Trop2 promotes growth and dissemination by the activation of the JAK2/STAT3 signaling pathway [68] and attenuates the expression of molecules downstream of this signaling pathway such as cyclin D1, survivin, matrix metalloproteinase 2 (MMP2), and vascular endothelial factor (VEGF).