NFKB1 and cancer: Furthermore, though separate studies identified NF-κB proteins, such as RelA, the downstream transcription factor of the canonical NF-κB pathway, as increasing cancer cell resistance to T-cell-induced death or increasing PD-L1 expression in ovarian cancer cells, little is known about the role of the noncanonical NF-κB pathway in regulating this immune checkpoint blockade in cancer cells [87,88].