Because it has been established that transcriptional activity of c-MYC (and related transcriptional signature) rather than c-MYC mRNA levels is a reliable predictor of poor prognosis in human HCC [34], we evaluated the correlation of FASN mRNA levels not only with c-MYC mRNA expression but also with c-MYC transcriptional activity. This evidence concerns the gene MYC and hepatocellular carcinoma.