Importantly, studies have found that while overexpression of c-MYC alone is unable to drive HCC formation in mice of C57BL/6 background due to extensive c-MYC induced hepatocyte death [22], concomitant overexpression of c-MYC and MCL1 promoted hepatocarcinogenesis in this genetic background [23]. This evidence concerns the gene MYC and hepatocellular carcinoma.