Since previously we demonstrated that HCC can compensate the loss of Fasn-dependent fatty acid production by increasing cholesterogenesis [37], we assessed the levels of cholesterol synthesis genes, such as Hydroxy-Methylglutaryl-CoA Reductase (Hmgcr), Mevalonate Kinase (Mvk), Squalene Synthase (Sqs) and Lanosterol Synthase (Lss), as well as the master cholesterol regulator, Sterol Regulatory Element Binding Transcription Factor 2 (Srebf2), in c-Myc/MCL1/Cre and c-Myc/MCL1/pCMV livers. Here, SREBF2 is linked to hepatocellular carcinoma.