In human HCC, previous studies conducted by several groups including ours revealed the augmented and coordinated expression of the major enzymes responsible for de novo lipogenesis, including FASN, ATP citrate lyase (ACLY), acetyl-CoA carboxylase (ACC), and stearoyl-coA desaturase (SCD) [28,29]. This evidence concerns the gene ACACA and hepatocellular carcinoma.