Similar data were reported in a recent study by Guri et al. In this study, the authors developed a mouse model consisting of loss of Tsc1 and Pten tumor suppressors in the liver (L-dKO mice), leading to liver-specific overactivation of the mTOR pathway and consequent fatty acid synthesis, liver steatosis, and hepatocarcinogenesis. Here, TSC1 is linked to neoplasm.