Specifically, while tumors rapidly emerged in the liver parenchyma of c-Myc/MCL1 wild-type mice, resulting in high tumor burden by 5-6 weeks post hydrodynamic injection, a comparable tumor burden was observed only 36 weeks post injection in c-Myc/MCL1 mice depleted of FASN (c-Myc/MCL1/Cre mice). The gene discussed is MCL1; the disease is neoplasm.