Subsequently, DEGs of the turquoise module were displayed in the global regulatory network to identify the intersection pathways of PRKCB, which supported the pleiotropic roles of PRKCB in AD pathophysiology responsible for gap junction [18], FcγR-mediated phagocytosis [31], MAPK and VEGF signaling pathways [16, 38]. This evidence concerns the gene VEGFA and Alzheimer disease.