Among them, 2,365 DEGs with 1,205 down-regulated and 1,160 up-regulated were established in AD patients compared to controls (Figure 2B); whereas 4,679 DEGs with 2,356 down-regulated and 2,323 up-regulated were identified in subjects with low versus high expression of PRKCB (Figure 2C). The gene discussed is PRKCB; the disease is Alzheimer disease.