Notably, a recent GWAS meta-analysis of T2D in 433,530 East Asians has uncovered independent signals in this region that distinctly colocalize with either an eQTL for NKX6-3 in islet or an eQTL for ANK1 expression in skeletal muscle and subcutaneous adipose tissues.37 This evidence concerns the gene ANK1 and type 2 diabetes mellitus.