Similarly, the designation of islet signals at the MTNR1B (rs10830963; PPA = 1.0; TOA = 1.0) and IGF2BP2 (rs150111048; PPA = 0.94; TOA = 0.96) loci was consistent with colocalized eQTLs implicating MTNR1B and IGF2BP2 as effector genes at these loci influencing T2D risk through effects on human islet function.6 The gene discussed is MTNR1B; the disease is type 2 diabetes mellitus.