For example, T2D signals assigned to adipose by the TOA classifier were enriched for variants associated with traits relevant to fat distribution (e.g., waist-to-hip ratio adjusted for BMI, 3.5-fold, p value < 0.0001), whereas signals assigned to liver and islet were enriched for SNPs associated with total cholesterol levels (3.3-fold, p value = 0.0011) and acute insulin response (2.3-fold, p value = 0.009), respectively (Figure S8). Here, INS is linked to type 2 diabetes mellitus.