In conclusion, our bioinformatics analysis identified 208 DEGs, eight hub genes (CDC20, BUB1, TOP2A, RRM2, CCNA2, UBE2C, MAD2L1), and the mitotic cell cycle pathway that might play an momentous role in the development and prognosis of SCLC. This evidence concerns the gene MAD2L1 and small cell lung carcinoma.