As shown in Fig 9A, Sulforafan and Irinotecan promoted the expression of CDC20, while Sunitinib, Methotrexate, Fluorouracil, Dasatinib and Oxaliplatin inhibited the expression of CDC20. This suggested that Sunitinib, Methotrexate, Fluorouracil, Dasatinib, and Oxaliplatin might be viewed as targeted drug for the treatment of SCLC patients with high expression of CDC20. Interestingly, the interaction between Cisplatin or Paclitaxel and CDC20 were controversial, and the conclusions drawn in different studies were inconsistent. This evidence concerns the gene CDC20 and small cell lung carcinoma.