PGR and Uterine leiomyoma: At present, several classes of compounds, such as gonadotropin-releasing hormone agonist (GnRHa, leuprolide acetate), GnRH antagonist (cetrorelix acetate), selective progesterone receptor modulators (ulipristal acetate/asoprisnil), antiprogestin (mifepristone), and natural compounds such as vitamin D and resveratrol (polyphenol extract) have been studied as medical treatments that target ECM in uterine leiomyoma [9].