A burden test aggregating low-frequency and rare coding variants in genes showed a significant positive association between TMPRSS5 and prevalent MI (P = 2.59 × 10−6) and LDLRAD1 and prevalent CHD (P = 1.30 × 10−6), and a significant protective association between RC3H2 and incident MI (P = 2.99 × 10−6). This evidence concerns the gene LDLRAD1 and myocardial infarction.