Analyses of breast cancer patients from Kaplan-Meier Plotter (https://kmplot.com/analysis/index.php?p=service&cancer=breast) also suggested that high expression of individual key enzymes, such as PRPS2, CAD, GMPS, and phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), correlated with poor patients’ survival (S1D–S1G Fig). This evidence concerns the gene PAICS and cancer.