PAICS and breast carcinoma: Analyses of breast cancer patients from Kaplan-Meier Plotter (https://kmplot.com/analysis/index.php?p=service&cancer=breast) also suggested that high expression of individual key enzymes, such as PRPS2, CAD, GMPS, and phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), correlated with poor patients’ survival (S1D–S1G Fig).