Through high-throughput expression profiling, WGCNA, lasso, and multivariate Cox analysis, we acquired eight genes (HCK, HAVCR2, CD37, LPAR5, NAGA, C1QC, FCER1G and AIF1) to construct the MRGs signature in Grade II/III glioma patients. Here, LPAR5 is linked to central nervous system cancer.