Through high-throughput expression profiling, WGCNA, lasso, and multivariate Cox analysis, we acquired eight genes (HCK, HAVCR2, CD37, LPAR5, NAGA, C1QC, FCER1G and AIF1) to construct the MRGs signature in Grade II/III glioma patients. The gene discussed is FCER1G; the disease is central nervous system cancer.